In addition to classical toxicological in vitro assays, we also can test new substances for drug development in human tissue-specific 2D and 3D cell culture models on a cellular level. In this setting, very sensitive test methods enable us to register and document minimal alterations of cellular processes under in vivo-like conditions.

By this, the pharmaceutical industry in advance can obtain preliminary information on tolerability of a substance.

We offer Cytotoxicity assay for active substances in conventional monolayer (2D) as well as in human tissue-specific 3D cell culture models. If more precise results are required, we offer 3D reconstructions of serial slides to measure the size and volume of affected tissue areas. Thus we can provide high-quality data for the comparison of treated and untreated tissue. Further we perform molecular and cellular biological studies on morphology, proliferation, differentiation, inflammation and apoptosis.

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Spectrum of methods

  • Toxicological Pathology
  • Immunohistology
  • xCelligence-based proliferation assay
  • RT-PCR for individual biomarkers or as biomarker-screening profiler.
  • Protein expression analysis

Services

  • Toxicological studies
  • Biocompatibility studies
  • If more precise results are required, we offer 3D reconstructions of serial slides to measure the size and volume of affected tissue areas. Thus we can provide high-quality data for the comparison of treated and untreated tissue.
  • Cytotoxicity assay for active substances in conventional monolayer (2D) as well as in human tissue-specific 3D cell culture models from skin, oral mucosa and cornea.
  • Molecular and cellular biological studies on morphology, proliferation,┬ádifferentiation, inflammation and apoptosis.